This seminar will focus on the IRB application review process from the IRB panelist's perspective. Researchers and IRB panels have a common aim to protect research participants in the conduct of human research. In this session, panelists will discuss their approach to reviewing an application and determining whether it meets established criteria for approval. Resources on the IRB website will be described, with an emphasis on how IRB panels use these in the review process. Panelists will share examples of strategies that researchers can use to help reviewers decide whether human subjects will be adequately protected in the proposed research through the protocol, consent documentation, consent process, and clarity of communication in the application.